　　王焕岭（女），华中农业大学教授。研究方向：分子遗传与鱼类育种。

一、教育简历

　　2001/09-2006/06，华中农业大学动物科技学院，动物遗传育种与繁殖，博士

　　1997/09-2001/06，河北农业大学动物科技学院，畜牧，学士

王焕岭（女），华中农业大学教授，鱼类育种专家。

二、工作简历

　　2019/12 - 至今，华中农业大学，水产学院，教授

　　2012/05 - 2013/06，美国哈佛大学，医学院，访问学者

　　2011/01 - 至今，华中农业大学，水产学院，博士生导师

　　2009/01 - 2019/11，华中农业大学，水产学院，副教授

　　2006/07 - 2008/12，华中农业大学，水产学院，讲师

三、教学成果

　　指导的本科生获得湖北省优秀学士论文3篇；

　　指导的本科生获得第十二届“挑战杯”全国大学生课外学术科技作品竞赛二等奖1项

　　指导的研究生湖北省和校级优秀硕士论文共3篇；

四、科研项目

　　1、国家自然科学基金面上项目，低氧胁迫下团头鲂miR-462-731介导的Akt-FoxO通路在调控线粒体功能中的作用机制，2019-2022

　　2、广西科技重大专项，广西主导（特色）水产种质资源的收集、评价与鉴定，2017-2021

　　3、广西水产遗传育种与健康养殖重点实验室开放基金，miRNA在凡纳滨对虾氨氮适应中的功能研究，2017-2018

　　4、中央高校专项基金，2662015PY205，鱼类特异的miR-462-731簇在低氧调节中的作用机制，2016-2017

　　5、留学回国人员科研启动基金，miR-462/731簇在HIF-1α介导的低氧调节中的作用及功能，2015-2016

　　6、中央高校专项基金，2013PY067，团头鲂耐低氧性状优良品系选育研究，2013-2015

　　7、教育部新世纪优秀人才计划项目，2010年，水产

　　8、国家自然科学基金青年项目，RNA干扰沉默HIF-1在几种鱼类低氧调节中的分子机理研究，2010-2012

　　9、国际科学基金（IFS），Population structure and genetic diversity of Chinese sucker in the Yangzte river basin，2009-2011

华中农业大学

五、科研论文

　　1、Huang CX, Huang Y, Duan XK, Zhang M, Tu JP, Liu JX, Liu H, Chen TS, Wang WM, Wang HL*. Zebrafish miR-462-731 regulates hematopoietic specification and pu.1-dependent primitive myelopoiesis. Cell Death Differ. 2018 Nov 20. doi: 10.1038/s41418-018-0234-0 (IF:8.0)

　　2、Chen N, Huang CX, Huang CH, He Y, Chen TS, Zhu DM, Liu H, Wang WM, Wang HL*. The molecular characterization, expression pattern and alternative initiation of Hif prolyl hydroxylase Phd1. Gene, 2018, 678: 219-225 (IF:2.415)

　　3、He Y, Huang CX, Chen N, Wu M, Huang Y, Liu H, Tang R, Wang WM, Wang HL*.The zebrafish miR-125c is induced under hypoxic stress via hypoxia-inducible factor 1α and functions in cellular adaptations and embryogenesis.Oncotarget. 2017, 8 (43) : 73846-73859 (IF:5.165)

　　4、Chen N, Wu M, Wang HJ, Liu H, Wang WM, Wang HL*. Effects of Acute Hypoxia and Reoxygenation on Physiological and Immune Responses and Redox Balance of Wuchang Bream (Megalobrama amblycephala Yih, 1955), Front. Physiol., 2017, 8:375 (IF:4.134)

　　5、Chen BX, Yi SK, Wang WF, He Y, Huang Y, Gao ZX, Liu H, Wang WM, Wang HL*.Transcriptome comparison reveals insights into muscle response to hypoxia in blunt snout bream (Megalobrama amblycephala). Gene. 2017, 624:6-13. (IF:2.415)

　　6、Huang CX, Chen N, Wu XJ, He Y, Huang CH, Liu H, Wang WM, Wang HL*. Zebrafish let-7b acts downstream of hypoxia-inducible factor-1α to assist in hypoxia-mediated cell proliferation and cell cycle regulation. Life Sciences, 2017, 171:21-29 (IF:2.936)

　　7、Huang CH, Chen N, Huang CX, Zhang B, Wu M, He L, Liu H, Tang R, Wang WM, Wang HL*, Involvement of miR-462/731 cluster in hypoxia response in Megalobrama amblycephala. Fish Physiol Biochem, 2017, 43(3):863-873 (IF:1.647)

　　8、Wu M, Chen N, Huang CX, He Y, Zhao YZ, Chen XH, Chen XL*, and Wang HL*. Effect of Low Temperature on Globin Expression, Respiratory Metabolic Enzyme Activities, and Gill Structure of Litopenaeus vannamei. Biochemistry (Moscow), 2017, 82(7): 844-851 (IF:1.537)

　　9、Huang CX, Chen N, Wu XJ, Huang CH, He Y, Tang R, Wang WM, Wang HL*. The zebrafish miR-462/miR-731 cluster is induced under hypoxic stress via hypoxia-inducible factor 1α and functions in cellular adaptations. FASEB J. 2015, 29(12): 4901-13 (IF:5.043)

　　10、Chen N, Wang WM, Wang HL*. An efficient full-length cDNA amplification strategy based on bioinformatics technology and multiplexed PCR methods. Sci Rep, 2016，5:19420. (IF:5.578)

华中农业大学校徽

　　11、Zhang B, Chen N, Huang CH, Huang CX, Chen BX, Liu H, Wang WM, Wang HL*, Molecular response and association analysis of Megalobrama amblycephala fih-1 with hypoxia, Mol Genet Genomics, 2016, 291(4): 1615-24 (IF: 2.728)

　　12、Chen N, Huang CH, Liu H, Chen BX, Wang WM, Wang HL*. Alternative splicing transcription of Megalobrama amblycephala HIF prolyl hydroxylase PHD3 and up-regulation of PHD3 by HIF-1α. Biochem Biophys Res Commun, 2016, 469(3): 737-42. (IF:2.297)

　　13、Wang HJ, Huang CX, Chen N, Zhu KC, Chen BX, Wang WM, Wang HL*. Molecular characterization and mRNA expression of HIF-prolyl hydroxylase-2 (phd2) in hypoxia-sensing pathways from Megalobrama amblycephala. Comp Biochem Physiol B Biochem Mol Biol. 2015, 186:28-35 (IF:1.551)

　　14、Zhu KC, Yu DH, Zhao JK, Wang WM, Wang HL*. Morphological analysis and muscle-associated gene expression during different muscle growth phases of Megalobrama amblycephala. Genet Mol Res. 2015, 14(3):11639-51. (IF:0.775)

　　15、Xu MX, Huang CX, Chen N, Wu XJ, Zhu KC,Wang WM, Wang HL*, Sequence analysis and expression regulation of rbp4 by 9-cis-RA in Megalobrama amblycephala, Fish Physiol Biochem. 2015, 41(2):437-47 (IF:1.622)

　　16、Chen N, Wan XL, Huang CX, Wang WM, Liu H, Wang HL*. Study on the immune response to recombinant Hsp70 protein from Megalobrama amblycephala, Immunobiology, 2014, 219, 850–858 (IF:3.044)

　　17、Zhang J, Wei XL, Chen LP, Chen N, Xu MX, Huang C, Wang WM, Wang HL*. Characterization of a novel CC chemokine CCL4 in immune response induced by nitrite and its expression differences among three populations of Megalobrama amblycephala. Fish & shellfish immunology. 2014, 38(1), 88-95 (IF:2.674)

　　18、Zhu KC, Wang HL*, Wang HJ, Yasmeen Gul, Yang M, Zeng C, Wang WM, Characterization of muscle morphology and satellite cells, and expression of muscle-related genes in skeletal muscle of juvenile and adult Megalobrama amblycephala, Micron, 2014, 64, 66–75 (IF:1.988)

　　19、Zhu KC, Chen LP, Zhao JK, Wang HJ, Wang WM, Li Z, Wang HL*.Molecular characterization and expression patterns of myogenin in compensatory growth of Megalobrama amblycephala.Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 2014,170, 10–17 (IF:1.551)

　　20、Huang CX, Wei XL, Chen N, Zhang J, Chen LP, Wang WM, Li JY, Wang HL*.Growth differentiation factor 9 of Megalobrama amblycephala: molecular characterization and expression analysis during the development of early embryos and growing ovaries. Fish Physiol Biochem. 2014, 40(1):193-203 (IF:1.622)

　　21、Zhang J, Wei XL, Chen LP, Chen N, Li YH, Wang WM, Wang HL*.Sequence analysis and expression differentiation of chemokine receptor CXCR4b among three populations of Megalobrama amblycephala, Dev Comp Immunol, 2013, 40(2):195-201 (IF:3.705)

　　22、Chen LP, Zhang J, Wei XL, Chen N, Huang CX, Xu MX, Wang WM, Wang HL*.Megalobrama amblycephala cardiac troponin T variants: Molecular cloning, expression and response to nitrite. Gene, 2013, 527(2):558-64 (IF:2.082)

　　23、Liu SS, Zhu KC, Chen N, Wang WM, Wang HL*.Identification of HIF-1α promoter and expression regulation of HIF-1α gene by LPS and hypoxia in zebrafish,Fish Physiol Biochem, 2013, 39(5):1153-63 (IF:1.676)

　　24、Chen N, Chen LP, Zhang J, Chen C, Wei XL, Gul Y, Wang WM, Wang HL*,Molecular cloning, characterization and expression analysis of three hypoxia inducible factor alpha subunits, HIF-1α, HIF-2α and HIF-3α of the endangered hypoxia-sensitive freshwater species, Myxocyprinus asiaticus, Gene, 2012,498, 81-90 (IF:2.341)

　　25、Zhu KC, Wang HL*, Gul Y, Zhao YH, Wang WM, Liu SS, Expression characterization and the promoter activity analysis of zebrafish hdac4,Fish Physiol Biochem, 2012, 38(2), 585-93 (IF:1.545)

　　26、Chen N, Wang WM, Wang HL*.Isolation of polymorphic microsatellite loci from an endangered freshwater species Chinese sucker, Myxocyprinus asiaticus,Conserv Genet Resour, 2010, 2, 73–75 (IF:1.255)

　　27、Zhu KC, Wang WM, Yan BL, Gul Y, Wang HL*.Development of polymorphic microsatellite markers for the swimming crab, Portunus trituberculatus (Miers, 1876), Conserv Genet Resour, 2010, 2, 117–119 (IF:1.255)

　　28、韦新兰，张杰，陈丽萍，王卫民，高泽霞，王焕岭＊，团头鲂SPATA4基因的分子克隆及表达分析，华中农业大学学报，2013, 32, 99-104

　　29、吴鑫杰，陈楠，黄春筱，王慧娟，王卫民，王焕岭＊. 低氧对团头鲂心肌细胞凋亡及抗氧化酶活性的影响，华中农业大学学报，2016,35(3):108-113